BMT Tandem Meetings

 
 
 

The 2013 BMT Tandem Meetings took place February 13-17 in Salt Lake City, Utah.

 

Lower uric acid levels may protect against GVHD

Erilyn Riley Read Article
Published: 02/27/13

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Skin biopsy showing GVHD
Credit: PLOS ONE

Lower uric acid levels at the time of allogeneic stem cell transplantation may protect against acute graft-vs-host disease (aGVHD), particularly in matched unrelated donor transplants. Researchers made this discovery when comparing patients who had received rasburicase, which degrades uric acid, shortly before transplant to patients who did not receive the drug. Albert Yeh, a Harvard Medical School student, presented the team’s findings as abstract 62 at the 2013 BMT Tandem Meetings. [Read Article]

TNF inhibitor effective for IPS in children

Erilyn Riley Read Article
Published: 02/23/13

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CT images showing IPS
Credit: NIH

The tumor necrosis factor (TNF) inhibitor etanercept has shown promising results in children with idiopathic pneumonia syndrome (IPS), according to data presented at the 2013 BMT Tandem Meetings. IPS is a noninfectious, diffuse lung injury that occurs after stem cell transplant. It has the signs and symptoms of pneumonia but without lower respiratory tract infection. Mortality rates with IPS are historically high, ranging from 50% to 75%. And reports have suggested that standard steroid . . .  [Read Article]

Busulfan’s ‘little sister’ provides good conditioning

Erilyn Riley Read Article
Published: 02/20/13

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Vials and a syringe

Treosulfan-containing conditioning regimens can provide efficient engraftment with low toxicity in children and adolescents, according to data presented at the 2013 BMT Tandem Meetings. Calling treosulfan the “little sister” of busulfan, Christina Peters, MD, PhD, of St Anna Children’s Hospital in Vienna, Austria, described some of the results achieved with this kinder, gentler alkylating agent. Dr Peters and her colleagues analyzed 616 children younger than 18 years who underwent . . . [Read Article]

HSCT is feasible for adults with severe SCD

Erilyn Riley Read Article
Published: 02/19/13

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Attendees at the 2013
BMT Tandem Meetings

Adults with sickle cell disease (SCD) are generally considered too sick to undergo hematopoietic stem cell transplant (HSCT), even using a nonmyeloablative approach. But transplant can be an option for these patients, according to Matthew Hsieh, MD, of the National Institutes of Health in Bethesda, Maryland. Dr Hsieh presented data supporting this statement at the 2013 BMT Tandem Meetings, which took place February 13-17 in Salt Lake City, Utah. [Read Article]

Second allograft possible, even in adults

Erilyn Riley Read Article
Published: 02/18/13

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Robert Lown, MD

Outcomes after second allograft have historically been dismal, about 11% overall survival for primary graft failure. However, published data are limited. And so the British Society of Blood and Marrow Transplantation analyzed patient outcomes after second allogeneic transplant, with some surprising results. Robert Lown, MD, of the UK charity organization Anthony Nolan, presented the interim analysis at the 2013 BMT Tandem Meetings, held February 13-17 in Salt Lake City, Utah. [Read Article]

Select patients over 70 may be transplant candidates

Erilyn Riley Read Article
Published: 02/16/13

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Andrew M. Brunner, MD

Age over 70 years often makes people with hematologic malignancies ineligible for transplant. However, a retrospective study on outcomes in older patients may begin to change that notion. Data presented at the 2013 BMT Tandem Meetings suggested that carefully selected older patients may, in fact, be candidates for hematopoietic stem cell transplant (HSCT). Andrew M. Brunner, MD, of Massachusetts General Hospital, reviewed the findings as abstract 10. [Read Article]

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