Cord Blood Symposium 2013

 
 
 

San Francisco; Photo by Basil D. Soufi.

The 11th Annual International Cord Blood Symposium took place June 6-8, 2013, in San Francisco, California.

 

Expert says NIMA typing is important for CBT

Jen Smith Read Article
Published: 06/20/13

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Andromachi Scaradavou, MD

Non-inherited maternal antigens (NIMA) play a role in the outcome of cord blood transplants (CBTs) and should therefore be considered when selecting cord blood units, according to a speaker at the 11th Annual International Cord Blood Symposium. A number of studies have suggested that patients who received NIMA-matched CBTs fare better than their non-NIMA-matched peers. So including NIMA matching as a factor in the search for cord blood units substantially . . . [Read Article]

CB product provides durable engraftment

Jen Smith Read Article
Published: 06/17/13

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Cord blood donation

An expanded cord blood product called NiCord can provide long-lasting engraftment in patients with high-risk hematologic malignancies, according to data presented at the 11th Annual International Cord Blood Symposium. A majority of patients in this small, phase 1/2 study achieved early platelet and neutrophil engraftment with NiCord. And, in some patients, that engraftment has persisted for 2 years. Joanne Kurtzberg, MD, of Duke University in Durham, North Carolina, presented . . . [Read Article]

Virus-specific T-cell lines can clear HSCT-related infections

Jen Smith Read Article
Published: 06/13/13

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Ann Leen, PhD

Researchers have generated T-cell lines that can be used to clear cytomegalovirus (CMV), adenovirus (ADV), and Epstein-Barr virus (EBV) in a variety of patients, according to a presentation at the 11th Annual International Cord Blood Symposium. The investigators administered the virus-specific T cells (VSTs) to patients who developed these infections after allogeneic hematopoietic stem cell transplant. Though the infections were refractory to prior treatments, a majority of . . . [Read Article]

Cord blood more than ‘acceptable’ stem cell source, speaker says

Jen Smith Read Article
Published: 06/12/13

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Cord blood donation
Credit: NHS

Cord blood is not just “viable” or “acceptable;” it’s a good source of stem cells for transplantation, according to a speaker at the 11th Annual International Cord Blood Symposium. He presented results of a retrospective, single-center study showing that outcomes in patients who received cord blood transplants (CBTs) were non-inferior to those of patients who received unrelated donor (URD) transplants. Rates of disease-free survival and non-relapse mortality were . . . [Read Article]

High-resolution HLA typing has a role in single CBT

Jen Smith Read Article
Published: 06/11/13

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Mary Eapen, MBBS

Results of a new study support the use of high-resolution HLA typing in single-unit cord blood transplants. Patients who received transplants matching at HLA-A, B, C, and DRB1 (8/8 loci) had higher rates of neutrophil recovery and lower rates of non-relapse mortality than their mismatched peers. Transplant recipients with 7/8 matching loci had similar outcomes to patients with 6/8 matching loci, both of which were superior to outcomes with 4 or 5 matching loci.  [Read Article]

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