AABB 2013


The AABB Annual Meeting & CTTXPO 2013 took place October 12-15 in Denver, Colorado.


Babesia screening eliminates infectious blood

Jen Smith Read Article
Published: 10/28/13

Collecting blood samples
Credit: Jeremy L. Grisham

Screening blood donors for the transfusion-transmissible parasite Babesia microti is feasible and effective, according to a new study. Previous research has suggested the antibody and DNA tests used to detect the tick-borne parasite may not be suitable for blood donor screening. Blood samples may be too small to enable accurate results, parasites may be present at insufficient levels for detection, and antibodies are not present in the circulation during a window period in early infection.  [Read Article]

Iron supplements speed Hb recovery for blood donors

Jen Smith Read Article
Published: 10/24/13

Blood donation
Credit: Charles Haymond

Daily iron supplementation significantly accelerates hemoglobin recovery after blood donation, according to results of the HEIRS study. Researchers found that iron supplements decreased hemoglobin recovery time in both iron-depleted and iron-replete donors. Iron-depleted donors had baseline ferritin levels of 26 ng/mL or less, and iron-replete donors had levels greater than 26 ng/mL. These results suggest iron supplementation programs may be more effective than other strategies for . . . [Read Article]

Study reveals misuse of plasma

Jen Smith Read Article
Published: 10/23/13

Bags of plasma
Credit: Cristina Granados

A new analysis suggests US hospitals may be transfusing plasma inappropriately. Researchers evaluated data from 10 hospitals and discovered both over-utilization and insufficient dosing of plasma. They found that 23% of plasma doses were given to patients who had an internal normalized ratio (INR) of 1.5 or less and therefore did not require a transfusion according to guidelines. On the other hand, the median dose of plasma the patients received—6.1 mL/kg—is approximately half of the recommended dose. [Read Article]

A step toward miRNA-based therapies for GVHD

Jen Smith Read Article
Published: 10/21/13

Skin biopsy showing GVHD
Courtesy of PLOS ONE

Investigators have identified several microRNAs (miRNAs) that may be suitable therapeutic targets for graft-vs-host disease (GVHD). Results of the team’s in vitro study appear to confirm the previously identified miR-155 as a target and have revealed miR-31, miR-15b, miR-142, miR-511, and miR-513 as potential targets. Renée Bazin, PhD, of Héma Québec in Canada, presented these findings at the recent AABB Annual Meeting & CTTXPO 2013. [Read Article]

Transfusion practices not changing, study suggests

Jen Smith Read Article
Published: 10/18/13

Blood for transfusion
Credit: Elise Amendola

Despite growing concerns about blood storage lesions, a new analysis indicates the average age of transfused blood has not changed in recent years. It is still unclear whether older blood negatively affects patient outcomes, as existing data both support and refute the idea. But a number of studies have shown that red blood cells (RBCs) can undergo detrimental changes during storage—such as oxidation, disruption of cellular structure, and loss of flexibility. [Read Article]

Environment is key determinant of RBC survival, speaker says

Jen Smith Read Article
Published: 10/17/13

Red blood cells
Credit: NHLBI

Red blood cells (RBCs) derived from critically ill neonates survive about as long after transfusion as RBCs derived from healthy adults, results of a small study suggest. This indicates it is the environment surrounding the RBCs that primarily impacts their survival, according to investigator Demet Nalbant, PhD, of the University of Iowa College of Medicine in Iowa City. She described this research and its implications at the AABB Annual Meeting & CTTXPO 2013. [Read Article]

Transfusing patients with a high risk of death

Jen Smith Read Article
Published: 10/16/13

Blood for transfusion
Credit: UAB Hospital

In a study of more than 200,000 hospital admissions, researchers found that nearly a quarter of blood transfusions were given to patients who ultimately died. These data suggest a need to re-evaluate the concept of “life-saving” blood transfusions and the utility of transfusing patients with a high risk of death, according to investigator Nadine Shehata, MD, of Mount Sinai Hospital in Toronto. Dr Shehata presented the data at the AABB Annual Meeting & CTTXPO 2013. [Read Article]


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